Grant funding totals $8.35 million in 2008
The Pediatric Brain Tumor Foundation (PBTF) increased its medical research funding commitments by $8.35 million in 2008.
The grants consist of an additional $6 million to the PBTF Institute at Duke University; $1 million to the PBTF Institute at the University of California, San Francisco; $1 million to PBTF Institute at the Hospital for Sick Children in Toronto, Canada; $250,000 to Dr. Gregory Shackleford at Children's Hospital Los Angeles; and $100,000 to Dr. Uri Tabori at the Hospital for Sick Children.
The PBTF's research institute program concluded its sixth year of funding in 2008. Total PBTF Institute funding now exceeds $14 million.
Overall, the foundation has funded more than 50 research institutions in the United States and other countries.
PBTFI Program at Duke University
Grant Award 2003-2008: $12 million
Director: Darell D. Bigner, M.D., Ph.D.
- Hai Yan, M.D., Ph.D.
Systematic Oncogenomic Profiling of Pediatric Astrocytoma - Joseph Nevins, Ph.D. and Bryan Cullen, Ph.D.
Utilization of Combined mRNA and microRNA Expression Profiles to Identify New Therapeutic Opportunities in Pediatric Brain Tumors - Francis Ali-Osman, D.Sc.
Genetics of DNA Damage Response and DNA Repair in Childhood Astrocytic Tumors - Sally Kornbluth, Ph.D.
Eliminating Brain Cancer Cells Through Apoptosome Activation - Wei Chen, Ph.D.
Clinical Treatment of Pediatric Medulloblastoma Using Novel Small Molecule Inhibitors of Smoothed Activity: A Translational Approach - Hui-Wen Lo, Ph.D.
Targeting STAT3 as a Novel Therapy for Pediatric Medulloblastomas - Jeremy Rich, M.D.
Targeting Pediatric Central Nervous System Cancer Stem Cells - Robert Wechsler-Reya, Ph.D.
Initiation and Propagation of Medulloblastoma - John Sampson, M.D., Ph.D.
Dendritic Cell Vaccines Targeting Medulloblastoma and Medulloblastoma Stem Cells - Michael Zalutsky, Ph.D.
Targeted Radiotherapy of Medulloblastoma - Darell Bigner, M.D., Ph.D. and Chien-Tsun Kuan, Ph.D.
Specific Antigen -Targeted Immunotherapy of Medulloblastoma - Roger McLendon, M.D.
Biorepository Core - Darell Bigner, M.D., Ph.D., and Henry Friedman, M.D.
Cell Lines and Xenograft Core - Michael Graner, Ph.D., and Oscar Alzate, Ph.D.
Discovery Proteomics Core - Darell Bigner, M.D., Ph.D.
Administrative Core; Developmental Research Core and Career Development Program
PBTF Institute at University of California, San Francisco
Grant Award 2005-2008: $1,300,000
Director: Mitchel S. Berger, M.D.
- David Rowitch, M.D., Ph.D., and Arturo Alvarez-Buylla, Ph.D.
Central Nervous System Development and Brain Stem Glioma Tumorigenesis - William A. Weiss, M.D., Ph.D.
MYCN and Medulloblastoma Tumorigenesis - Graeme Hodgson, Ph.D. and Nalin Gupta, M.D., Ph.D.
Novel Therapeutic Strategies for Pediatric Brain Tumors - Scott VandenBerg, M.D, Ph.D.
Tissue Bank Core - C. David James, Ph.D.
Animal Core - Mitchel S. Berger, M.D.
Administrative and Statistical Core
PBTF Institute, Hospital for Sick Children
Grant Award 2005-2008: $1,300,000
Director: James T. Rutka, M.D., Ph.D., FRCSC, FACS, FAAP
- James Rutka, M.D., Ph.D., Michael D. Taylor, M.D., Ph.D. and Peter Dirk. M.D., Ph.D.
The Role of Isochromosome 17Q in the Pathogenesis of Pediatric Brain Medulloblastoma
Basic Research Awards
- Gregory Shackleford, Ph.D., Children's Hospital Los Angeles, $250,000
Transgenic models of medulloblastoma - Uri Tabori, M.D., Hospital for Sick Children, $100,000
Predictors of outcomes in long-term survivors of pediatric low-grade gliomas
